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2027 formulary updates

Express Scripts® Pharmacy Benefit Services continues its commitment to clinically appropriate, cost-effective prescription drug coverage. Changes to our annual formularies are available now.

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2027 annual formulary updates

Effective January 1, 2027, Express Scripts is introducing the annual formulary enhancements across National Preferred, Flex, Basic, and High Performance formularies. These updates focus on excluding high‑cost products that do not demonstrate additional clinical value, while preserving access to preferred, clinically appropriate alternatives. 

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What's changing

National Preferred and Flex Formularies

Twenty-nine additional products will be excluded.

99.89% of National Preferred members1 will have no pharmacy counter disruption.

View the list of new National Preferred Formulary exclusions and preferred alternatives

National Preferred Flex Formulary

Twenty-eight additional products will be excluded.

99.97% of National Preferred Flex members1 are expected to have no pharmacy counter disruption.

View the list of new Flex Formulary exclusions and preferred alternatives

Basic and High Performance Formularies

Additional optimization opportunities identified to support client and member savings.

View the list of annual 2027 status updates

Previous updates

2026 mid‑year formulary updates

Effective July 1, 2026, Express Scripts is introducing mid‑year formulary enhancements across National Preferred, Flex, Basic, and High‑Performance formularies. These updates focus on excluding high‑cost products that do not demonstrate additional clinical value, while preserving access to preferred, clinically appropriate alternatives. 

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What's changed

National Preferred and Flex Formularies

Thirteen additional products will be excluded.

99.98% of National Preferred members and 100% of Flex members are expected to have no pharmacy counter disruption.

View the list of new National Preferred Formulary exclusions and preferred alternatives

View the list of new Flex Formulary exclusions and preferred alternatives

Basic and High‑Performance Formularies

Additional mid‑year optimization opportunities identified to support client and member savings.

View the list of new exclusions and preferred alternatives

Basic and High Performance Formularies

Additional optimization opportunities identified to support client and member savings.

View the list of annual 2027 status updates

As previously communicated, STELARA® SC will be excluded from the National Preferred Formulary effective July 1, 2026, and will transition to non‑preferred status on the Basic Formulary. This aligns with a broader strategy to improve affordability and access through biosimilar options. 

Client and member support:

No action is required from consultants

Clients were notified of these changes on March 17, 2026

Members required to switch medications will receive individualized communications, including alternative options and transition guidance

Annual changes to the Basic and High Performance Formularies

Additional opportunities were identified for Basic and High Performance to help client and member savings. Detailed 2026 annual status updates for these formularies are now available.

What you need to know

Supporting clients and their members

The small percentage of members being asked to switch to preferred medications will receive personalized outreaches, including a list of            alternative medications and information on switching to a preferred product.

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Questions? Contact our team.

Source

  1. Express Scripts® National Preferred Formulary and National Preferred Flex Formulary members claim utilization, April – August 2026.